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MRT67307 hydrochloride

SIGMA/SML0702 - ≥98% (HPLC)

Synonym: N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide hydrochloride

CAS Number: 1190378-57-4 (free base)
Empirical Formula (Hill Notation): C26H36N6O2 · xHCl
Molecular Weight: 464.60 (free base basis)
Linear Formula: C26H36N6O2 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0702-5MG 5 mg
 $148.00
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45-SML0702-25MG 25 mg
 $599.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
InChI key UKBGBACORPRCGG-UHFFFAOYSA-N
Quality Level 100 
SMILES string N5(CCOCC5)Cc1cc(ccc1)Nc2nc(c(cn2)C4CC4)NCCCNC(=O)C3CCC3
solubility H2O: 15 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation.
Biochem/physiol Actions: MRT67307 is a dual inhibitor of the IKKe and TBK-1.
Biochem/physiol Actions: MRT67307 is a dual inhibitor of the IKKe and TBK-1. IKKe and TBK-1 mediate the phosphorylation of interferon regulatory factor 3 (IRF3).
Biochem/physiol Actions: MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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