1-Methylnicotinamide chloride
SIGMA/SML0704 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 1005-24-9
Empirical Formula (Hill Notation): C7H9ClN2O
Molecular Weight: 172.61
Linear Formula: C7H9ClN2O
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C7H8N2O.ClH/c1-9-4-2-3 |
| InChI key | BWVDQVQUNNBTLK-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.[n+]1(cc(ccc1)C(=N)[O- |
| solubility | H2O: 15 mg/mL, clear |
| storage temp. | room temp |
| Biochem/physiol Actions: | 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT. |
| Biochem/physiol Actions: | 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide with antithrombotic and anti-inflammatory effects. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |