DDRI-18

SIGMA/SML0710 - ≥98% (HPLC)

Synonym: 3,3′-[6,6′-bi-1H-Benzimidazole]-2,2′-diylbis-benzenamine

CAS Number: 4402-18-0
Empirical Formula (Hill Notation): C₂₆H₂₀N₆
Molecular Weight: 416.48
MDL Number: MFCD01137750
Linear Formula: C₂₆H₂₀N₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0710-5MG	5 mg	$92.10 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C26H20N6/c27-19-5-1-3-17(11-19)25-29-21-9-7-15(13-23(21)31-25)16-8-10-22-24(14-16)32-26(30-22)18-4-2-6-20(28)12-18/h1-14H,27-28H2,(H,29,31)(H,30,32)
InChI key	QROWVLFOWUYBIG-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC1=CC=CC(C(N2)=NC(C=C3)=C2C=C3C4=CC5=C(C=C4)N=C(N5)C6=CC(N)=CC=C6)=C1
solubility	DMSO: 10 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	DDRI-18 (DNA Damage Response Inhibitor-18) inhibits nonhomologous end-joining (NHEJ) DNA repair following double strand DNA breaks induced by ionizing radiation, and enhances the effects of DNA-damaging cancer drugs like etoposide, camptothecin and doxorubicin.
Biochem/physiol Actions:	DDRI-18 (DNA Damage Response Inhibitor-18) inhibits nonhomologous end-joining (NHEJ) DNA repair.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335 - H413
Precautionary statements	P273 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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