FSLLRY-NH2 trifluoroacetate salt

SIGMA/SML0714 - ≥98% (HPLC)

CAS Number: 245329-02-6 (free base)
Empirical Formula (Hill Notation): C₃₉H₆₀N₁₀O₈ · xC₂HF₃O₂
Molecular Weight: 796.96 (free base basis)
Linear Formula: C₃₉H₆₀N₁₀O₈ · xC₂HF₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0714-1MG	1 mg	$122.00 1/EAAdd To Favorites	Add To Favorites

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assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1
InChI key	KMSCNWHRNILNRJ-JNRWAQIZSA-N
Quality Level	100
shipped in	wet ice
storage temp.	−20°C

Amino Acid Sequence:	Phe-Ser-Leu-Leu-Arg-Tyr-NH₂ trifluoroacetate salt
Application:	FSLLRY-NH2 trifluoroacetate salt has been used as a protease-activated receptor 2 (PAR2) inhibitor to test its effects on urinary tract infections (UTIs) in a murine model. It has also been used to study the clinical itch datasets from phase 3 clinical trials for moderate-to-severe AD in atopic dermatitis (AD)-associated acute itch flare mice modelin rats.
Biochem/physiol Actions:	FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assays, the peptide inhibits agonist-induced cardiocyte remodeling, and production of cytokines by endothelial cells.
Biochem/physiol Actions:	The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests that PAR2 is involved in the maintenance of VH.
Packaging:	1 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200