FSLLRY-NH2 trifluoroacetate salt
SIGMA/SML0714 - ≥98% (HPLC)
CAS Number: 245329-02-6 (free base)
Empirical Formula (Hill Notation): C39H60N10O8 · xC2HF3O2
Molecular Weight: 796.96 (free base basis)
Linear Formula: C39H60N10O8 · xC2HF3O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to off-white |
form | powder |
Quality Level | 100 |
shipped in | wet ice |
storage temp. | −20°C |
Amino Acid Sequence: | Phe-Ser-Leu-Leu-Arg-Tyr-N |
Application: | FSLLRY-NH2 trifluoroacetate salt has been used as a protease-activated receptor 2 (PAR2) inhibitor to test its effects on urinary tract infections (UTIs) in a murine model. It has also been used to study the clinical itch datasets from phase 3 clinical trials for moderate-to-severe AD in atopic dermatitis (AD)-associated acute itch flare mice modelin rats. |
Biochem/physiol Actions: | FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assays, the peptide inhibits agonist-induced cardiocyte remodeling, and production of cytokines by endothelial cells. |
Biochem/physiol Actions: | The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests that PAR2 is involved in the maintenance of VH. |
Packaging: | 1 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |