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Methazolamide

SIGMA/SML0720 - ≥98% (HPLC)

Synonym: 5-Acetylimino-4-methyl-ยท2-1,3,4-thiadiazoline-2-sulfonamide; N-(4-Methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene) acetamide; L 584601; N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

CAS Number: 554-57-4
Empirical Formula (Hill Notation): C5H8N4O3S2
Molecular Weight: 236.27
EC Number: 209-066-7
MDL Number: MFCD00083416
Linear Formula: C5H8N4O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0720-50MG 50 mg
 $148.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
InChI key FLOSMHQXBMRNHR-QPJJXVBHSA-N
mp 208 °C (dec.) (lit.)
Quality Level 100 
SMILES string CN1N=C(SC1=NC(C)=O)S(N)(=O)=O
solubility DMSO: 20 mg/mL, clear
storage condition protect from light
storage temp. 2-8°C
Biochem/physiol Actions: Cell-permeable and potent carbonic anhydrase (CA) inhibitor
Biochem/physiol Actions: Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.
Biochem/physiol Actions: Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
Other Notes: Light sensitive
Packaging: 50 mg in glass bottle
Purity ≥98% (HPLC)
mp 208 °C (dec.) (lit.)
Storage Temp. 2-8°C
UNSPSC 12352200

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