Synonym: (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese; (Salen)manganese(III) chloride; Chloro(bis(salicylidene)ethylenediamine)manganese; Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese; EUK 8; Manganese(salen) chloride
CAS Number: 53177-12-1
Empirical Formula (Hill Notation): C16H14ClMnN2O2
Molecular Weight: 356.69
Linear Formula: C16H14ClMnN2O2
Product Type: Chemical
assay |
≥95% (HPLC) |
color |
, faint to very dark brown |
form |
powder |
InChI |
1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3 |
InChI key |
HBQGFROGWOHBAG-UHFFFAOYSA-K |
Quality Level |
100 |
solubility |
H2O: 1 mg/mL, clear |
storage condition |
desiccated |
storage temp. |
−20°C |
Biochem/physiol Actions: |
EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils. |
Other Notes: |
air sensitive |
Packaging: |
10, 50 mg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥95% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |