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EUK-8

SIGMA/SML0742 - ≥95% (HPLC)

Synonym: (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese; (Salen)manganese(III) chloride; Chloro(bis(salicylidene)ethylenediamine)manganese; Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese; EUK 8; Manganese(salen) chloride

CAS Number: 53177-12-1
Empirical Formula (Hill Notation): C16H14ClMnN2O2
Molecular Weight: 356.69
Linear Formula: C16H14ClMnN2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0742-10MG 10 mg
 $141.00
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45-SML0742-50MG 50 mg
 $532.00
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assay ≥95% (HPLC)
color , faint to very dark brown
form powder
InChI 1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3
InChI key HBQGFROGWOHBAG-UHFFFAOYSA-K
Quality Level 100 
SMILES string [Mn]1(Oc2c(cccc2)C=NCCN=Cc3c(cccc3)O1)Cl
solubility H2O: 1 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: EUK-8 is a salen manganese complex that exhibit potent antioxidant activities.
Biochem/physiol Actions: EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.
Other Notes: air sensitive
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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