Synonym: (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese; 2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex; Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2′,O1,O1′]-manganese; EUK 134
CAS Number: 81065-76-1
Empirical Formula (Hill Notation): C18H18ClMnN2O4
Molecular Weight: 416.74
Linear Formula: C18H18ClMnN2O4
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
, faint to very dark brown |
| form |
powder |
| Quality Level |
100  |
| solubility |
H2O: 2 mg/mL, clear (warmed) |
| storage condition |
desiccated |
| storage temp. |
−20°C |
| Application: |
EUK-134 has been used as an antioxidant. |
| Application: |
EUK-134 has been used to determine the mechanism underlying hypoxia-inducible factor-1α (HIF-1α) stabilization in human aortic endothelial cells (HAECs). |
| Biochem/physiol Actions: |
EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils. |
| Other Notes: |
air sensitive |
| Packaging: |
10, 50 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
