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EUK-134

SIGMA/SML0743 - ≥95% (HPLC)

Synonym: (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese; 2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex; Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2′,O1,O1′]-manganese; EUK 134

CAS Number: 81065-76-1
Empirical Formula (Hill Notation): C18H18ClMnN2O4
Molecular Weight: 416.74
Linear Formula: C18H18ClMnN2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0743-10MG 10 mg
 $85.70
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45-SML0743-50MG 50 mg
 $335.00
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assay ≥95% (HPLC)
color , faint to very dark brown
form powder
InChI 1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3
InChI key YUZJJFWCXJDFOQ-UHFFFAOYSA-K
Quality Level 100 
SMILES string [Mn+2]Cl.N(=Cc2c(c(ccc2)OC)[O-])CCN=Cc1c(c(ccc1)OC)[O-]
solubility H2O: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. −20°C
Application: EUK-134 has been used as an antioxidant.
Application: EUK-134 has been used to determine the mechanism underlying hypoxia-inducible factor-1α (HIF-1α) stabilization in human aortic endothelial cells (HAECs).
Biochem/physiol Actions: EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities and inhibits amyloid fibril formation.
Biochem/physiol Actions: EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.
Other Notes: air sensitive
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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