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LDN-27219

SIGMA/SML0744 - ≥98% (HPLC)

Synonym: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide

CAS Number: 312946-37-5
Empirical Formula (Hill Notation): C20H16N4O2S2
Molecular Weight: 408.50
Linear Formula: C20H16N4O2S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0744-5MG 5 mg
 $115.00
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45-SML0744-25MG 25 mg
 $307.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H16N4O2S2/c21-23-16(25)12-28-20-22-18-17(15(11-27-18)13-7-3-1-4-8-13)19(26)24(20)14-9-5-2-6-10-14/h1-11H,12,21H2,(H,23,25)
InChI key WLBUICQBNZXIDJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string [s]1c2nc([n]([c](c2c(c1)c4ccccc4)=O)c3ccccc3)SCC(=O)NN
solubility DMSO: 15 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) that binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.
Biochem/physiol Actions: LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2).
Biochem/physiol Actions: LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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