NS6180
SIGMA/SML0745 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 353262-04-1
Empirical Formula (Hill Notation): C16H12F3NOS
Molecular Weight: 323.33
Linear Formula: C16H12F3NOS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1) The IC50 of NS6180 against cloned human KCa3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07,GHS09 |
Signal word | Warning |
Hazard statements | H317 - H411 |
Precautionary statements | P273 - P280 - P302 + P352 |
Hazard Codes | Xi,N |
Risk Statements | 43-51/53 |
Safety Statements | 61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |