SC79
SIGMA/SML0749 - ≥97% (NMR)
Synonym: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
CAS Number: 305834-79-1
Empirical Formula (Hill Notation): C17H17ClN2O5
Molecular Weight: 364.78
Linear Formula: C17H17ClN2O5
Product Type: Chemical
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| assay | ≥97% (NMR) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H17ClN2O5/c1-3-23-1 |
| InChI key | DXVKFBGVVRSOLI-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Clc1cc2c(cc1)OC(=C(C2C(C( |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid. |
| Biochem/physiol Actions: | SC79 is an AKT activator. |
| Biochem/physiol Actions: | SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. SC79 induces cytosolic Akt signaling in cell based assays, and prevents neuronal death in a mouse model of stroke. |
| Features and Benefits: | This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (NMR) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |