SC144 hydrochloride
SIGMA/SML0763 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 917497-70-2
Empirical Formula (Hill Notation): C16H11FN6O · HCl
Molecular Weight: 358.76
Linear Formula: C16H11FN6O · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | SC144 hydrochloride has been used: • as a glycoprotein 130 (gp130) inhibitor to evaluate the effect of bazedoxifene on interleukin (IL-6) mediated cell viability in pancreatic cancer cells • as a gp130 inhibitor to study its effects on signal transducer and activator of transcription 3 (STAT3) activation in mesenchymal precursor cells (KMM) cel • as an interleukin 6 signal transducer (IL-6ST) inhibitor in media to test its ability to block serum-induced migration/invasion |
| Biochem/physiol Actions: | SC144 is a potent inhibitor of glycoprotein 130 (gp130). SC144 binds to gp130 and blocks STAT3 phosphorylation, nuclear translocation and expression of STAT3 responsive genes. SC144 inhibits the growth of several tumor cell lines, independent of p53 or hormone receptor levels, and inhibits growth of ovarain tumor xenografts in mice. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |