Synonym: DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide) trifluoroacetate salt; Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH2 trifluoroacetate salt
CAS Number: 106128-89-6
Empirical Formula (Hill Notation): C40H55N7O11S · xC2HF3O2
Molecular Weight: 841.97 (free base basis)
Linear Formula: C40H55N7O11S · xC2HF3O2
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
colorless |
| form |
film |
| InChI |
1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1 |
| InChI key |
HMHYXLVEFVGOPM-QKUYTOGTSA-N |
| Quality Level |
100  |
| shipped in |
wet ice |
| storage condition |
desiccated |
| storage temp. |
−20°C |
| Amino Acid Sequence: |
Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH2 trifluoroacetate salt |
| Biochem/physiol Actions: |
Senktide is a selective Neurokinin NK3 tachykinin receptor agonist. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. |
| Biochem/physiol Actions: |
Senktide treatment in follicular phase goats enhances the liberation of luteinizing hormone (LH) and advance the time of ovulation. Senktide has the ability to suppress gonadotropin-releasing hormone (GnRH) transcription. Treatment with senktide stimulates c-Fos and improve activator protein-1 (AP-1) activity. |
| Packaging: |
500 μg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
