GSK2801

SIGMA/SML0768 - ≥98% (HPLC)

Synonym: 1-(7-(2-Methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone

Empirical Formula (Hill Notation): C₂₀H₂₁NO₄S
Molecular Weight: 371.45
MDL Number: MFCD26142953
Linear Formula: C₂₀H₂₁NO₄S
Product Type: Chemical

assay	≥98% (HPLC)
color	, white to pink to light brown
form	powder
InChI	1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
InChI key	KHWCPNJRJCNVRI-UHFFFAOYSA-N
Quality Level	100
SMILES string	CCCOC1=CC2=C(C3=CC=CC=C3S(=O)(C)=O)C=C(C(C)=O)N2C=C1
solubility	DMSO: 10 mg/mL, clear
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:	GSK2801 is a potent inhibitor of the BAZ2 family of bromodomain containing proteins. BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifying enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. For full characterization details, please visit the GSK2801 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits:	GSK2801 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes:	GSK2801 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK2801 probe summary on the Chemical Probes Portal website.
Other Notes:	Light sensitive
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable