LG100754

SIGMA/SML0771 - ≥98% (HPLC)

Synonym: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2,4,6-Octatrienoic acid

CAS Number: 180713-37-5
Empirical Formula (Hill Notation): C₂₆H₃₆O₃
Molecular Weight: 396.56
Linear Formula: C₂₆H₃₆O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0771-5MG	5 mg	$148.00 1/EA	Add To Favorites
45-SML0771-25MG	25 mg	$599.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11-
InChI key	HNODNXQAYXJFMQ-LQUSFLDPSA-N
Quality Level	100
SMILES string	O(CCC)c1cc2c(cc1C(=C/C=C/C(=C/C(=O)O)/C)C)C(CCC2(C)C)(C)C
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	LG100754 is a RXR:PPAR agonist.
Biochem/physiol Actions:	LG100754 is a unique RXR ligand that acts as an antagonist against RXR homodimers, but is a strong agonist for RXR:PPARα and RXR:PPARγ heterodimers. The compound does not have agonist activities for other RXR heterodimers containing LXR or GAR/FXR receptors. LG100754 initiates adipocyte differentiation, inhibits TNFα-induced insulin receptor hypophosphorylation and improves insulin resistance in db/db mice.
Features and Benefits:	This compound is featured on the InsR , Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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