Synonym: 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
CAS Number: 10140-70-2
Empirical Formula (Hill Notation): C16H20O5
Molecular Weight: 292.33
MDL Number: MFCD09752718
Linear Formula: C16H20O5
Product Type: Chemical
| assay |
≥98% (HPLC) |
| biological source |
Penicillium citrinum |
| form |
powder |
| InChI |
1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1 |
| InChI key |
VDUIGYAPSXCJFC-JTQLQIEISA-N |
| Quality Level |
200  |
| SMILES string |
OC1=C(C(CCCCC[C@H](C)O2)=O)C(CC2=O)=CC(O)=C1 |
| solubility |
DMSO: 1 mg/mL |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
S - Curvularin is a macrocyclic lactone with cytotoxic activity. Curvularin inhibits cell division as well as expression of human inducible nitric oxide synthase (iNOS), an enzyme critically involved in pro-inflammatory immune processes. Curvularin anti-inflammatory activity was demonstrated in chronic inflammatory disease models in mice such as Chronic Induced Arthritis (CIA) as well as in human alveolar epithelial A549/8 cells. |
| Biochem/physiol Actions: |
Curvularin is a macrocyclic lactone with cytotoxic activity. |
| Other Notes: |
Store the product sealed at −20 °C. Under these conditions the product is stable for at least 5 years. |
| Preparation Note: |
Soluble in DMSO (1 mg/mL), Chloroform (3 mg/mL) and Dichloromethane (3 mg/mL). Note: Insoluble in water. |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
51111800 |
