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GSK-650394

SIGMA/SML0773 - ≥98% (HPLC)

Synonym: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid; GSK 650394; GSK650394

CAS Number: 890842-28-1
Empirical Formula (Hill Notation): C25H22N2O2
Molecular Weight: 382.45
Linear Formula: C25H22N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0773-5MG 5 mg
 $165.00
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45-SML0773-25MG 25 mg
 $659.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
InChI key WVSBGSNVCDAMCF-UHFFFAOYSA-N
Quality Level 100 
SMILES string [nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3
solubility DMSO: 20 mg/mL, clear
storage temp. room temp
Application: GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.
Biochem/physiol Actions: GSK-650394 has an IC50 value of 62 nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103 nM for SGK2. It has an ability to stop viral replication at concentrations that are nontoxic to cells.
Biochem/physiol Actions: GSK-650394 is a potent and selective Serum- and glucocorticoid-regulated kinase 1 (SGK1) antagonist.
Biochem/physiol Actions: GSK-650394 is a potent, selective SGK1 antagonist.
Features and Benefits: This compound is featured on the PKB/Akt  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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