GR203040
SIGMA/SML0780 - ≥98% (HPLC)
Synonym: (2S,3S)
CAS Number: 168398-02-5
Empirical Formula (Hill Notation): C20H24N6O · 2HCl
Molecular Weight: 437.37
Linear Formula: C20H24N6O · 2HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C20H24N6O.2ClH/c1-27-1 |
InChI key | UYDCUPIPQXAELR-OINVMNEBSA |
Quality Level | 100 |
solubility | H2O: 10 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | GR203040 is a high affinity, non-peptide tachykinin NK1 receptor antagonist. GR203040 inhibits substance P binding to human NK1 receptors in CHO cells with a pKi or 10.3. The compound prevents emisis, and reduces bladder damage induced by radiation, cisplatin and cyclophosphamide. 11C-labeled GR203040 is used as a radioligand to image NK1 receptors in the CNS by PET scanning. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |