(-)-Umbellulone

SIGMA/SML0782 - ≥98% (HPLC)

Synonym: (1R, 5S)-4-Methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one; (1R,5S)-(-)-3-Thujen-2-one; Thujen-2-one; Thujenone

CAS Number: 546-78-1
Empirical Formula (Hill Notation): C₁₀H₁₄O
Molecular Weight: 150.22
Linear Formula: C₁₀H₁₄O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0782-5MG	5 mg	$77.90 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	Umbellularia californica Nutt.
color	colorless to light brown
form	oil
InChI	1S/C10H14O/c1-6(2)10-5-8(10)7(3)4-9(10)11/h4,6,8H,5H2,1-3H3/t8-,10+/m0/s1
InChI key	LTTVJAQLCIHAFV-WCBMZHEXSA-N
SMILES string	O=C1[C@@]2([C@@H](C2)C(=C1)C)C(C)C
storage condition	desiccated
storage temp.	−20°C

Biochem/physiol Actions:	(-)-Umbellulone is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels.
Biochem/physiol Actions:	(-)-Umbellulone, isolated from the"headache tree" Umbellularia californica Nutt, is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. (-)-Umbellulone activates TRPA1 channels on nociceptive trigeminal afferents, resulting in release of CGRP and CGRP-mediated neurogenic vasodilatation, causing a painful cold sensation and headache/migraine.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22-43
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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