(-)-Umbellulone
SIGMA/SML0782 - ≥98% (HPLC)
Synonym: (1R, 5S)
CAS Number: 546-78-1
Empirical Formula (Hill Notation): C10H14O
Molecular Weight: 150.22
Linear Formula: C10H14O
Product Type: Chemical
assay | ≥98% (HPLC) |
biological source | Umbellularia californica Nutt. |
color | colorless to light brown |
form | oil |
storage condition | desiccated |
storage temp. | −20°C |
Biochem/physiol Actions: | (-)-Umbellulone, isolated from the"headache tree" Umbellularia californica Nutt, is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. (-)-Umbellulone activates TRPA1 channels on nociceptive trigeminal afferents, resulting in release of CGRP and CGRP-mediated neurogenic vasodilatation, causing a painful cold sensation and headache/migraine. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22-43 |
Safety Statements | 36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |