AZ628
SIGMA/SML0785 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 878739-06-1
Empirical Formula (Hill Notation): C27H25N5O2
Molecular Weight: 451.52
Linear Formula: C27H25N5O2
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C27H25N5O2/c1-17-8-9-2 |
| InChI key | ZGBGPEDJXCYQPH-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [n]1([c](c2c(nc1)ccc(c2)N |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | AZ628 is a potent Raf kinase inhibitor with IC50 values of 105 nM for wild-type B-raf, 34 nM for Raf-B V600E and 29 nM for wild-type c-Raf-1. AZ628 is a type II inhibitor that binds to the catalytically inactive Asp-Phe-Gly (DFG)-out configuration. |
| Biochem/physiol Actions: | AZ628 is a potent Raf kinase inhibitor. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H315 - H319 - H335 |
| Precautionary statements | P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |