Synonym: (+)-Decursin; (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate; 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester
CAS Number: 5928-25-6
Empirical Formula (Hill Notation): C19H20O5
Molecular Weight: 328.36
Linear Formula: C19H20O5
Product Type: Chemical
| assay |
≥97% (HPLC) |
| biological source |
Radix peucedani |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1 |
| InChI key |
CUKSFECWKQBVED-INIZCTEOSA-N |
| optical activity |
[α]/D +120 to +160°, c = 0.5 in chloroform-d |
| Quality Level |
100  |
| shipped in |
wet ice |
| solubility |
DMSO: 5 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells. |
| Features and Benefits: |
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
1, 5 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥97% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
