A 83-01
SIGMA/SML0788 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 909910-43-6
Empirical Formula (Hill Notation): C25H19N5S
Molecular Weight: 421.52
Linear Formula: C25H19N5S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | −20°C |
Application: | A 83-01 has been used as an inhibitor of transforming growth factor β kinase type 1 receptor. |
Biochem/physiol Actions: | A 83-01 is a TGFβ kinase/activin receptor-like kinase (ALK 5) inhibitor (IC50=12 nM) that prevents phosphorylation of Smad2/3 and inhibits growth induced by TGFβ. A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Also, A 83-01 inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7. A-83-01 induces an expansion of neonatal Nkx2.5-eGFP (+) cells. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 - H315 - H319 - H335 |
Precautionary statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 - P337 + P313 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |