GI254023X

SIGMA/SML0789 - ≥98% (HPLC)

Synonym: (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide; GI4023

CAS Number: 260264-93-5
Empirical Formula (Hill Notation): C₂₁H₃₃N₃O₄
Molecular Weight: 391.50
MDL Number: MFCD19381832
Linear Formula: C₂₁H₃₃N₃O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0789-5MG	5 mg	$234.00 1/EA	Add To Favorites
45-SML0789-25MG	25 mg	$933.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1
InChI key	GHVMTHKJUAOZJP-CGTJXYLNSA-N
Quality Level	100
SMILES string	ON(C=O)[C@@H](C)[C@@H](CCCC1=CC=CC=C1)C(N[C@@H](C(C)(C)C)C(NC)=O)=O
solubility	DMSO: 15 mg/mL, clear
storage temp.	2-8°C

Application:	GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10).
Biochem/physiol Actions:	GI254023X blocks ADAM10 (ADAM metallopeptidase domain 10) activity and decreases human leukocyte antigen (HLA)-mediated cytotoxicity and cleavage of extracellular E-cadherin in epithelial and endothelial cells.
Biochem/physiol Actions:	GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). In a study using recombinant TACE and ADAM10 ectodomain, the IC₅₀ for GI254023X was 5.3 nM for ADAM10 vs 541 nM for TACE.
Biochem/physiol Actions:	GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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