GI254023X
SIGMA/SML0789 - ≥98% (HPLC)
Synonym: (2R)
CAS Number: 260264-93-5
Empirical Formula (Hill Notation): C21H33N3O4
Molecular Weight: 391.50
MDL Number: MFCD19381832
Linear Formula: C21H33N3O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C21H33N3O4/c1-15(24(28 |
InChI key | GHVMTHKJUAOZJP-CGTJXYLNSA |
Quality Level | 100 |
SMILES string | ON(C=O)[C@@H](C)[C@@H](CC |
solubility | DMSO: 15 mg/mL, clear |
storage temp. | 2-8°C |
Application: | GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10). |
Biochem/physiol Actions: | GI254023X blocks ADAM10 (ADAM metallopeptidase domain 10) activity and decreases human leukocyte antigen (HLA)-mediated cytotoxicity and cleavage of extracellular E-cadherin in epithelial and endothelial cells. |
Biochem/physiol Actions: | GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). In a study using recombinant TACE and ADAM10 ectodomain, the IC50 for GI254023X was 5.3 nM for ADAM10 vs 541 nM for TACE. |
Biochem/physiol Actions: | GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |