T2AA hydrochloride
SIGMA/SML0794 - ≥98% (HPLC)
Synonym: (S)
CAS Number: 1380782-27-3 (free base)
Empirical Formula (Hill Notation): C15H15I2NO3 · HCl
Molecular Weight: 547.55
Linear Formula: C15H15I2NO3 · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Application: | T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus. |
Biochem/physiol Actions: | T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |