T2AA hydrochloride
SIGMA/SML0794 - ≥98% (HPLC)
Synonym: (S)
CAS Number: 1380782-27-3 (free base)
Empirical Formula (Hill Notation): C15H15I2NO3 · HCl
Molecular Weight: 547.55
Linear Formula: C15H15I2NO3 · HCl
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C15H15I2NO3/c16-13-6-9 |
| InChI key | NKOSKXJRVWVXRI-JTQLQIEISA |
| Quality Level | 100  |
| SMILES string | Ic1c(c(cc(c1)C[C@H](N)CO) |
| solubility | DMSO: 10 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus. |
| Biochem/physiol Actions: | T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity. |
| Biochem/physiol Actions: | T2AA is an inhibitor of PCNA/ PIP-Box interactions; inhibits PCNA Polδ3 interaction. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |