PF-670462
SIGMA/SML0795 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 950912-80-8
Empirical Formula (Hill Notation): C19H20FN5 · 2HCl
Molecular Weight: 410.32
Linear Formula: C19H20FN5 · 2HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H20FN5.2ClH/c20-14- |
InChI key | PSNKGVAXBSAHCH-UHFFFAOYSA |
Quality Level | 100 |
solubility | H2O: 2 mg/mL, clear (warmed) |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC50 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity). |
Biochem/physiol Actions: | PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluo |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |