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PF-670462

SIGMA/SML0795 - ≥98% (HPLC)

Synonym: 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride; PF670462

CAS Number: 950912-80-8
Empirical Formula (Hill Notation): C19H20FN5 · 2HCl
Molecular Weight: 410.32
Linear Formula: C19H20FN5 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0795-5MG 5 mg
 $146.00
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45-SML0795-25MG 25 mg
 $591.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChI key PSNKGVAXBSAHCH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1ccc(cc1)c2nc[n](c2c4nc(ncc4)N)C3CCCCC3.Cl.Cl
solubility H2O: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC50 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity).
Biochem/physiol Actions: PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I.
Biochem/physiol Actions: PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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