HI-TOPK-032
SIGMA/SML0796 - ≥98% (HPLC)
Synonym: N-
CAS Number: 487020-03-1
Empirical Formula (Hill Notation): C20H11N5OS
Molecular Weight: 369.40
Linear Formula: C20H11N5OS
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | orange to dark red |
| form | powder |
| InChI | 1S/C20H11N5OS/c21-11-13-1 |
| InChI key | BCSBXWKRZUPFHW-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [s]1c(ccc1)C(=O)Nc2cc3[n] |
| solubility | DMSO: 3 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Application: | HI-TOPK-032 has been used as a PDZ binding-kinase (PBK) inhibitor. |
| Biochem/physiol Actions: | HI-TOPK-032 belongs to the class of ATP-competitive inhibitors. It can also be used as a potent therapeutic for colorectal cancer. |
| Biochem/physiol Actions: | HI-TOPK-032 is a specific TOPK (T-LAK cell–originated protein kinase) inhibitor both in vitro and in vivo. HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model. |
| Biochem/physiol Actions: | HI-TOPK-032 is a specific TOPK inhibitor. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |