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JIB-04

SIGMA/SML0808 - ≥98% (HPLC)

Synonym: (E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine

CAS Number: 199596-05-9
Empirical Formula (Hill Notation): C17H13ClN4
Molecular Weight: 308.76
Linear Formula: C17H13ClN4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0808-5MG 5 mg
 $129.00
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45-SML0808-25MG 25 mg
 $528.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
InChI key YHHFKWKMXWRVTJ-OQKWZONESA-N
Quality Level 100 
SMILES string Clc1cnc(cc1)NN=C(c3ncccc3)/c2ccccc2
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: JIB-04 has been used in sulforhodamine B cell growth assay. It has also been used as a control to determine the inhibitory action of ML324 on KDM4A (histone lysine demethylase 4A).
Biochem/physiol Actions: JIB-04 is a selective inihibitor of Jumonji demethylases without inhibiting other α-ketoglutarate-dependent hydroxylases or histone-modifying enzymes including amine oxidase LSD1 (also known as KDM1A), which demethylates histone lysines. JIB-04 is a pan-inhibitor of Jumonji demethylases with JARID1A (KDM5A) being the most sensitive (IC50=230 nM) followed by JMJD2D (IC50=290 nM) and JMJD3 (KDM6B) and JMJD2C (KDM4C) more resistant (IC50 855 and 1100 nM, respectively). JIB-04 selectively inhibited viability of several human cancer cell lines with little toxicity towards normal cells, and also diminished tumor growth in two separate xenograft mouse models.
Biochem/physiol Actions: JIB-04 is a selective inihibitor of Jumonji demethylases.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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