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MHY1485

SIGMA/SML0810 - ≥95% (HPLC)

Synonym: 4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

CAS Number: 326914-06-1
Empirical Formula (Hill Notation): C17H21N7O4
Molecular Weight: 387.39
Linear Formula: C17H21N7O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0810-5MG 5 mg
 $81.10
1/EA		 Add To Favorites
45-SML0810-25MG 25 mg
 $328.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
InChI key MSSXBKQZZINCRI-UHFFFAOYSA-N
Quality Level 100 
SMILES string [N+](=O)([O-])c1ccc(cc1)Nc2nc(nc(n2)N4CCOCC4)N3CCOCC3
solubility DMSO: 2 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: MHY1485 has been used:
• to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
• to inhibit autophagy
• as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis
Biochem/physiol Actions: MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.
Biochem/physiol Actions: MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
Biochem/physiol Actions: MHY1485 is mTOR activator: autophagy inhibitor.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the PKB/Akt  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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