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ESI-09

SIGMA/SML0814 - ≥98% (HPLC)

Synonym: α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile

CAS Number: 263707-16-0
Empirical Formula (Hill Notation): C16H15ClN4O2
Molecular Weight: 330.77
Linear Formula: C16H15ClN4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0814-5MG 5 mg
 $156.00
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45-SML0814-25MG 25 mg
 $621.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color , faint yellow to dark orange
form powder
InChI 1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
InChI key DXEATJQGQHDURZ-DEDYPNTBSA-N
Quality Level 100 
SMILES string Clc1cc(ccc1)NN=C(C(=O)c2n[o]c(c2)C(C)(C)C)/C#N
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC).
Biochem/physiol Actions: ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP).
Biochem/physiol Actions: ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41106305

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