ESI-09
SIGMA/SML0814 - ≥98% (HPLC)
Synonym: α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
CAS Number: 263707-16-0
Empirical Formula (Hill Notation): C16H15ClN4O2
Molecular Weight: 330.77
Linear Formula: C16H15ClN4O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | , faint yellow to dark orange |
form | powder |
Quality Level | 100 |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Application: | ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC). |
Biochem/physiol Actions: | ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 41106305 |