YM-08
SIGMA/SML0822 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 812647-88-4
Empirical Formula (Hill Notation): C19H17N3OS2
Molecular Weight: 367.49
Linear Formula: C19H17N3OS2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | yellow to orange |
| form | powder |
| Quality Level | 100  |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. |
| Biochem/physiol Actions: | YM-08 is a Heat Shock Protein 70 inhibitor that is blood-brain barrier permeable. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |