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FH1

SIGMA/SML0826 - ≥98% (HPLC)

Synonym: BRD-K4477; N,N′-(Methylenedi-4,1-phenylene)bis-acetamide; N,N′-(Methylenedi-4,1-phenylene)diacetamide; NSC 12407

CAS Number: 2719-05-3
Empirical Formula (Hill Notation): C17H18N2O2
Molecular Weight: 282.34
Linear Formula: C17H18N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0826-5MG 5 mg
 $83.30
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45-SML0826-25MG 25 mg
 $331.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)
InChI key OEXMNSOPAKOPEF-UHFFFAOYSA-N
Quality Level 100 
SMILES string N(c1ccc(cc1)Cc2ccc(cc2)NC(=O)C)C(=O)C
solubility DMSO: 10 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype than what had previouslybeen obtainable. Human induced pluripotent stem (iPS) cells that are differentiated toward hepatocyte-like (iHep) cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. Cultures treated with both FH1 (BRD-K4477) and another compound that induces proliferation, FPH1 (BRD-6125), contained larger colonies of iHep cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.
Biochem/physiol Actions: FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype.
Packaging: 5, 25 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H400
Precautionary statements P273
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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