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FPH1

SIGMA/SML0827 - ≥98% (HPLC)

Synonym: 2-(N-(5-Chloro-2-methylphenyl)(methylsulfonamido)-N-(2,6-difluorophenyl)-acetamide; 2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide; BRD-6125

CAS Number: 708219-39-0
Empirical Formula (Hill Notation): C16H15ClF2N2O3S
Molecular Weight: 388.82
Linear Formula: C16H15ClF2N2O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0827-5MG 5 mg
 $111.00
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45-SML0827-25MG 25 mg
 $448.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H15ClF2N2O3S/c1-10-6-7-11(17)8-14(10)21(25(2,23)24)9-15(22)20-16-12(18)4-3-5-13(16)19/h3-8H,9H2,1-2H3,(H,20,22)
InChI key WAOBCCBUTHNTFO-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1c(c(ccc1)F)NC(=O)CN([S](=O)(=O)C)c2c(ccc(c2)Cl)C
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro.
Biochem/physiol Actions: FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH1 induced hepatocyte colonies were used in conjunction with FH1 (BRD-K4477) to induce a more mature phenotype. Cultures treated with both FH1 and FPH1 contained larger colonies of hepatocyte-like (iHep) cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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