FPH2

SIGMA/SML0828 - ≥98% (HPLC)

Synonym: 4-(3-(5-Chloro-2-methoxyphenyl)thioxureido)-1-ethyl-1H-pyrazole-3-carboxamide; 4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide; BRD-9424

CAS Number: 957485-64-2
Empirical Formula (Hill Notation): C₁₄H₁₆ClN₅O₂S
Molecular Weight: 353.83
Linear Formula: C₁₄H₁₆ClN₅O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0828-5MG	5 mg	$140.00 1/EA	Add To Favorites
45-SML0828-25MG	25 mg	$528.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C14H16ClN5O2S/c1-3-20-7-10(12(19-20)13(16)21)18-14(23)17-9-6-8(15)4-5-11(9)22-2/h4-7H,3H2,1-2H3,(H2,16,21)(H2,17,18,23)
InChI key	PCHRYHSDDPPZBV-UHFFFAOYSA-N
Quality Level	100
SMILES string	S=C(Nc2c[n](nc2C(=O)N)CC)Nc1c(ccc(c1)Cl)OC
solubility	DMSO: 10 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	FPH2 (BRD-9424) induced functional proliferation of primary human hepatocytes in vitro.
Biochem/physiol Actions:	FPH2 (BRD-9424) induced functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH2 induced hepatocyte doublings at a rate consistent with reported liver regeneration kinetics. FPH2 can be used in conjunction with FH1 (BRD-K4477), which induces a more mature phenotype.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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