TLR4-IN-C34
SIGMA/SML0832 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 40592-88-9
Empirical Formula (Hill Notation): C17H27NO9
Molecular Weight: 389.40
Linear Formula: C17H27NO9
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H27NO9/c1-8(2)24-17 |
| InChI key | KMIQMFHPUJUDMC-HHARLNAUSA |
| Quality Level | 100  |
| SMILES string | N([C@H]1[C@H](O[C@@H]([C@ |
| solubility | H2O: 1 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | TLR4-IN-C34 has been used as an inhibitor in the HFD-feeding mice to verify the aforementioned in vitro pathway (stearic acid/LDH-a/cytokines) in vivo. |
| Biochem/physiol Actions: | TLR4-IN-C34 is a potent and specific inhibitor of toll-like receptor 4 (TLR4), which inhibits TLR4 signaling in vivo and in vitro. TLR4-IN-C34, also known as C34, is an aminomonosaccharide that inhibits TLR4 signaling by docking with the hydrophobic pocket of the TLR4 co-receptor, myeloid differentiation protein-2 (MD-2). C34 has been shown to diminish the severity of experimental necrotizing enterocolitis (NEC). |
| Biochem/physiol Actions: | TLR4-IN-C34 is a potent and specific inhibitor of toll-like receptor 4 (TLR4). |
| General description: | TLR4-IN-C34 is an inhibitor of toll-like receptor 4 (TLR4) in vitro and in vivo. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |