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HLY78

SIGMA/SML0833 - ≥98% (HPLC)

Synonym: 4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine; 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

CAS Number: 854847-61-3
Empirical Formula (Hill Notation): C17H17NO2
Molecular Weight: 267.32
Linear Formula: C17H17NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0833-5MG 5 mg
 $82.50
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45-SML0833-25MG 25 mg
 $492.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Activator of the Wnt/β-Catenin signaling pathway.
Biochem/physiol Actions: HLY78 is an activator of the Wnt/β-Catenin signaling pathway. HLY78 acts upstream of β-catenin synergistically with Wnt. It is believed to bind at a cavity at the dimeric interface of the Axin DIX domain, causing a conformational change of Axin to an active state, potentiating Axin–LRP6 association and promoting Wnt signaling transduction. There are several Wnt inhibitors used to study their potential in cancer therapy but few small molecules that activate the Wnt pathway. In Zebrafish, HLY78 increased the expression of the hematopoietic stem cell (HSC) transcription factors runx1 and cmyb, showing that it might be useful in HSC expansion, which could be important in transplantation and recovery after injury.
Packaging: 5, 25 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H410
Precautionary statements P273 - P501
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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