ML297
SIGMA/SML0836 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 1443246-62-5
Empirical Formula (Hill Notation): C17H14F2N4O
Molecular Weight: 328.32
Linear Formula: C17H14F2N4O
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H14F2N4O/c1-11-9-16 |
| InChI key | IEKSMUSSYJUQMY-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Fc1c(ccc(c1)NC(=O)Nc2[n]( |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | ML297 (VU0456810) is a potent and selective activator of the GIRK potassium channel. |
| Biochem/physiol Actions: | ML297 (VU0456810) is the first potent and selective activator of the GIRK potassium channel. The G protein-coupled inwardly-rectifying potassium channels (GIRKs 1-4) are widely distributed broadly in the central nervous system (GIRKs 1-3) and also found in the heart (GIRK-4). ML297 activates GIRK channels containing a GIRK1 subunit, and does not activate channels without a GIRK1 subunit or the closely related potassium channel Kir2.1 or voltage-gated potassium channels. ML297 has been shown to activate GIRK1/2 with a potency of ~160 nM and also to activate GIRK channels comprising of GIRK1/3 and GIRK1/4 subunit combinations. ML297 was active in two in vivo models of epilepsy, and showed equal or greater efficacy than the anti-seizure medication, sodium valproate. |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H410 |
| Precautionary statements | P273 - P501 |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |