Synonym: 1,2,4,5-Benzene tetraamine tetrahydrochloride; 1,2,4,5-Benzenetetraamine 4HCl; 1,2,4,5-Benzenetetraamine tetrahydrochloride; Benzene-1,2,4,5-tetramine tetrahydrochloride; NSC 667249; Y15
CAS Number: 4506-66-5
Empirical Formula (Hill Notation): C6H10N4 · 4HCl
Molecular Weight: 284.01
EC Number: 224-822-6
Linear Formula: C6H10N4 · 4HCl
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
, faint purple to dark brown |
| form |
powder |
| InChI |
1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H |
| InChI key |
BZDGCIJWPWHAOF-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
[Cl-].[Cl-].[Cl-].[Cl-].Nc1c(cc(c(c1)N)N)N.[H+].[H+].[H+].[H+] |
| solubility |
H2O: 20 mg/mL, clear |
| storage condition |
desiccated |
| storage temp. |
room temp |
| Application: |
FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion. |
| Biochem/physiol Actions: |
1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. |
| Biochem/physiol Actions: |
1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis. |
| Features and Benefits: |
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
10, 50 mg in glass bottle |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
