PACMA 31
SIGMA/SML0838 - ≥98% (HPLC)
Synonym: N-
CAS Number: 1401089-31-3
Empirical Formula (Hill Notation): C21H22N2O6S
Molecular Weight: 430.47
MDL Number: MFCD26793891
Linear Formula: C21H22N2O6S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| InChI | 1S/C21H22N2O6S/c1-5-18(24 |
| InChI key | AHOOZADJPNUFOQ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | C#CC(N(C(C1=CC=CS1)C(NCC( |
| solubility | DMSO: 10 mg/mL, clear (warmed) |
| storage temp. | room temp |
| Biochem/physiol Actions: | Both in vivo and in vitro studies reveal that PACMA 31 possesses anti-tumor function, especially observed in ovarian cancer. |
| Biochem/physiol Actions: | PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model. |
| Biochem/physiol Actions: | PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI). |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |