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GNF 5837

SIGMA/SML0844 - ≥98% (HPLC)

Synonym: N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N′-[2-fluoro-5-(trifluoromethyl)phenyl]-urea

CAS Number: 1033769-28-6
Empirical Formula (Hill Notation): C28H21F4N5O2
Molecular Weight: 535.49
Linear Formula: C28H21F4N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0844-5MG 5 mg
 $165.00
1/EA		 Add To Favorites
45-SML0844-25MG 25 mg
 $659.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow to orange
form powder
InChI 1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
InChI key YYDUWLSETXNJJT-MTJSOVHGSA-N
Quality Level 100 
SMILES string FC(F)(F)c1cc(c(cc1)F)NC(=O)Nc2cc(c(cc2)C)Nc3cc4c(cc3)C(=Cc5[nH]ccc5)C(=O)N4
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: GNF-5837 is a selective Trk inhibitor.
Biochem/physiol Actions: GNF-5837 is an orally bioavailable Trk inhibitor (IC50 = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC50 values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 36/37/39
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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