Anagrelide hydrochloride
SIGMA/SML0846 - ≥98% (HPLC)
Synonym: 6,7-
CAS Number: 58579-51-4
Empirical Formula (Hill Notation): C10H7Cl2N3O · HCl
Molecular Weight: 292.55
Linear Formula: C10H7Cl2N3O · HCl
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C10H7Cl2N3O.ClH/c11-6- |
| InChI key | TVWRQCIPWUCNMI-UHFFFAOYSA |
| Quality Level | 100  |
| solubility | DMSO: 1 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC50 = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets. |
| Biochem/physiol Actions: | Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity. |
| Biochem/physiol Actions: | In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis. |
| Features and Benefits: | This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Download the CofA, SDS and IFU specific to your product lot and format  Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase. After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl2, 0.1 mM ZnCl2, 1% bovine serum albumin (w/v), pH 7.6. Clone: polyclonal Ig class: sheep IgG, Fab fragments |
| General description: | Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41106305 |