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LM22A-4

SIGMA/SML0848 - ≥98% (HPLC)

Synonym: N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

CAS Number: 37988-18-4
Empirical Formula (Hill Notation): C15H21N3O6
Molecular Weight: 339.34
Linear Formula: C15H21N3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0848-5MG 5 mg
 $130.00
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45-SML0848-25MG 25 mg
 $425.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
InChI key RGWJKANXFYJKHN-UHFFFAOYSA-N
Quality Level 100 
SMILES string N(CCO)C(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO
solubility H2O: 2 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.
Biochem/physiol Actions: LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression.
Biochem/physiol Actions: LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC50 of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome.
Biochem/physiol Actions: LM22A-4 is a partial agonist of TrkB.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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