Synonym: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid; Tetrabromocinnamic acid
CAS Number: 934358-00-6
Empirical Formula (Hill Notation): C9H4Br4O2
Molecular Weight: 463.74
Linear Formula: C9H4Br4O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+ |
| InChI key |
SVJQCVOKYJWUBC-OWOJBTEDSA-N |
| Quality Level |
100  |
| SMILES string |
Brc1c(c(cc(c1Br)C=CC(=O)O)Br)Br |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
2-8°C |
| Application: |
Tetrabromocinnamic acid (TBCA) has been used in protein-fragment complementation assay, in an approach to identify inhibitors of αsyn oligomerization. |
| Biochem/physiol Actions: |
Tetrabromocinnamic acid (TBCA) is a selective casein kinase CK2 inhibitor. |
| Biochem/physiol Actions: |
Tetrabromocinnamic acid (TBCA) is a selective cell-permeable ATP-competitive casein kinase CK2 inhibitor with an IC50 of 110 nM, 2-fold selectivity over CK1, and with the advantage of being less active on DYRK1A (IC50 = 24.5 μM) than other CK2 inhibitors suh as DMAT. Elevated levels of CK2 are associated with many cancers and also with tau hyperphosphorylation and neuropathology found in Alzheimer′s disease and other neurodegenerative disorders. In prostate cancer cells TBCA reduced cell proliferation and caused G2/M cell cycle arrest. In isolated squid axoplasms, TBCA also blocked inhibition of fast axonal transport by Aβ oligomers. |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard statements |
H413 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
