HQL 79
SIGMA/SML0857 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 162641-16-9
Empirical Formula (Hill Notation): C22H27N5O
Molecular Weight: 377.48
Linear Formula: C22H27N5O
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C22H27N5O/c1-3-8-18(9- |
| InChI key | TZQGXAHOROZEKN-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [nH]1nnnc1CCCN2CCC(CC2)OC |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | room temp |
| Biochem/physiol Actions: | HQL 79 is an orally active anti-allergic agent that acts as an antagonist for histamine H1 receptors (H1R), eliciting anti-asthmatic effects. It interacts with prostaglandin (PG) D synthase (H-PGDS) in the catalytic region. It may be potential lead due to its H-PGDS inhibition to treat allergies. |
| Biochem/physiol Actions: | HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase, one of two synthases involved in the production of Prostaglandin D2 (PGD2) from arachidonic acid. PGD2 is a lipid signaling molecule, which activates two receptors, DP1 involved in centrally mediated processes such as sleep and pain and DP2 involved and inflammation. The two PGD synthases involved in its synthesis are lipocalin-type (L-PGDS) and hematopoietic (H-PDGS), which acts to form PGD2 in mast cells, Th2 cells, microglia, and other inflammatory cells/tissues. HQL-79 selectively inhibited the activity of recombinant H-PGDS with an IC50 of 6 μM and had almost no effect on COX-1, COX-2, m-PGES, or L-PGDS up to 300 μM. HQL-79 has anti-inflammatory activity in vitro and in vivo. |
| Biochem/physiol Actions: | HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 41106300 |