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AA92593

SIGMA/SML0865 - ≥98% (HPLC)

Synonym: 1-(4-Methoxy-3-methyl-benzenesulfonyl)-piperidine; 1-[(4-Methoxy-3-methylphenyl)sulfonyl]-piperidine; Cy1001

CAS Number: 457961-34-1
Empirical Formula (Hill Notation): C13H19NO3S
Molecular Weight: 269.36
Linear Formula: C13H19NO3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0865-5MG 5 mg
 $139.00
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45-SML0865-25MG 25 mg
 $527.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H19NO3S/c1-11-10-12(6-7-13(11)17-2)18(15,16)14-8-4-3-5-9-14/h6-7,10H,3-5,8-9H2,1-2H3
InChI key HDTKLZINZGEPFG-UHFFFAOYSA-N
Quality Level 100 
SMILES string [S](=O)(=O)(N2CCCCC2)c1cc(c(cc1)OC)C
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Application: AA92593 has been used as a selective melanopsin inhibitor.
Biochem/physiol Actions: AA92593 blocks melanopsin activity and stimulates α-melanocyte-stimulating hormone (α-MSH) expression and induces melanin distribution in the melanophores, which darkens the embryo.
Biochem/physiol Actions: AA92593 is an opsinamide, a potent antagonist of melanopsin-mediated phototransduction with an IC50 of 665 nM in a Ca2+ flux assay in CHO cells expressing melanopsin (Opn4) and selectivity > 10 μM at 74 common biological targets. AA41612 is believed to act by competing for binding to melanopsin. AA41612 inhibited mouse pupillary light reflex and light aversion in vivo. AA92593 and similar compounds might be useful in alleviating the photophobia associated with migraine.
Biochem/physiol Actions: AA92593 is an opsinamide, a potent antagonist of melanopsin-mediated phototransduction.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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