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Y16

SIGMA/SML0873 - ≥98% (HPLC)

Synonym: 4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione

CAS Number: 429653-73-6
Empirical Formula (Hill Notation): C24H20N2O3
Molecular Weight: 384.43
Linear Formula: C24H20N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0873-5MG 5 mg
 $121.00
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45-SML0873-25MG 25 mg
 $110.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color , faint yellow to dark orange
form powder
InChI 1S/C24H20N2O3/c1-17-7-5-9-19(13-17)16-29-21-12-6-8-18(14-21)15-22-23(27)25-26(24(22)28)20-10-3-2-4-11-20/h2-15H,16H2,1H3,(H,25,27)
InChI key ITMLWGWTDWJSRZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string N2(NC(=O)C(=Cc3cc(ccc3)OCc4cc(ccc4)C)C2=O)c1ccccc1
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). Y16 specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways. Y16 blocks the growth and migration of MCF7 breast cancer cells.
Biochem/physiol Actions: Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GTP Binding Proteins (Low Molecular Weight)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes: Product is a racemic mixture of E/Z isomers.
Packaging: 5, 25 mg in glass bottle
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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