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Aurora-A Inhibitor I

SIGMA/SML0882 - ≥98% (HPLC)

Synonym: TC‐S7010; N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide; N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide

CAS Number: 1158838-45-9
Empirical Formula (Hill Notation): C31H31ClFN7O2
Molecular Weight: 588.07
Linear Formula: C31H31ClFN7O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0882-5MG 5 mg
 $145.00
1/EA		 Add To Favorites
45-SML0882-25MG 25 mg
 $574.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)
InChI key AKSIZPIFQAYJGF-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1c(nc(nc1)Nc4ccc(cc4)CC(=O)N5CCN(CC5)CC)Nc2ccc(cc2)C(=O)Nc3c(cccc3)Cl
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay.
Biochem/physiol Actions: Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A with an IC50 of 3.4 nM and 1000-fold selectivity for Aurora A over Aurora B (better than VX-680) and even higher for CDKs. Antiproliferative IC50 values were in the vicinity of 1 μM against the human colorectal cancer cell line HCT116.
Biochem/physiol Actions: Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A.
Biochem/physiol Actions: Aurora-A Inhibitor I, also known as TC‐S7010, stimulates G2/M cell cycle arrest and apoptosis in ARID1A −/− cells.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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