bpV(HOpic)
SIGMA/SML0884 - ≥90% V basis
Synonym: Bisperoxovanadium(HOpic); Dipotassium bisperoxo (5-
CAS Number: 722494-26-0
Empirical Formula (Hill Notation): K2VOO2O2C6H4NO3
Molecular Weight: 347.24
Linear Formula: K2VOO2O2C6H4NO3
Product Type: Chemical
| assay | ≥90% V basis |
| color | faintly yellow to dark yellow |
| form | powder |
| Quality Level | 100  |
| solubility | H2O: 20 mg/mL, clear |
| storage condition | desiccated |
| protect from light | |
| storage temp. | −20°C |
| Application: | bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway. |
| Biochem/physiol Actions: | bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury. |
| Other Notes: | Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% V basis |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |