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bpV(pic)

SIGMA/SML0885 - ≥95% V basis

Synonym: Dipotassium Bisperoxovanadium(pic) dihydrate; Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate; K2 [VO(O2)2C6H4NO2] ยท 2 H2O

CAS Number: 148556-27-8
Empirical Formula (Hill Notation): K2VOO2O2C6H4NO2 · 2H2O
Molecular Weight: 367.27
Linear Formula: K2VOO2O2C6H4NO2 · 2H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0885-5MG 5 mg
 $107.00
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45-SML0885-25MG 25 mg
 $431.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥95% V basis
color faintly yellow to dark yellow
form powder
Quality Level 100 
solubility H2O: 20 mg/mL, clear
storage condition protect from light
storage temp. −20°C
Application: bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.
Biochem/physiol Actions: bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.
Biochem/physiol Actions: bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
Biochem/physiol Actions: bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN).
Other Notes: Light Sensitive
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319
Precautionary statements P302 + P352 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% V basis
Storage Temp. −20°C
UNSPSC 12352200

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