bpV(pic)
SIGMA/SML0885 - ≥95% V basis
Synonym: Dipotassium Bisperoxovanadium(pic) dihydrate; Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate; K2 [VO(O2)2C6H4NO2] ยท 2 H2O
CAS Number: 148556-27-8
Empirical Formula (Hill Notation): K2VOO2O2C6H4NO2 · 2H2O
Molecular Weight: 367.27
Linear Formula: K2VOO2O2C6H4NO2 · 2H2O
Product Type: Chemical
| assay | ≥95% V basis |
| color | faintly yellow to dark yellow |
| form | powder |
| Quality Level | 100  |
| solubility | H2O: 20 mg/mL, clear |
| storage condition | protect from light |
| storage temp. | −20°C |
| Application: | bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription. |
| Biochem/physiol Actions: | bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses. |
| Biochem/physiol Actions: | bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK). |
| Other Notes: | Light Sensitive |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% V basis |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |