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Leukadherin-1

SIGMA/SML0886 - ≥98% (HPLC)

Synonym: 4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid; LA1; Leukadhedrin 1; Leukadherin 1

CAS Number: 344897-95-6
Empirical Formula (Hill Notation): C22H15NO4S2
Molecular Weight: 421.49
Linear Formula: C22H15NO4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0886-5MG 5 mg
 $93.50
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45-SML0886-25MG 25 mg
 $366.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color , yellow to orange to brown
form powder
InChI 1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
InChI key AEZGRQSLKVNPCI-UNOMPAQXSA-N
Quality Level 100 
SMILES string S1C(=C/c3[o]c(cc3)c4ccc(cc4)C(=O)O)C(=O)N(C1=S)Cc2ccccc2
solubility DMSO: 3 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.
Biochem/physiol Actions: Leukadherin-1 is an agonist of integrin CD11b/CD18
Biochem/physiol Actions: Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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