Leukadherin-1
SIGMA/SML0886 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 344897-95-6
Empirical Formula (Hill Notation): C22H15NO4S2
Molecular Weight: 421.49
Linear Formula: C22H15NO4S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | , yellow to orange to brown |
form | powder |
Quality Level | 100 |
solubility | DMSO: 3 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels. |
Biochem/physiol Actions: | Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |