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bpV(phen)

SIGMA/SML0889 - ≥95% V basis

Synonym: Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate

CAS Number: 42494-73-5 (anhydrous)
Empirical Formula (Hill Notation): KVO5C12H8N2 · xH2O
Molecular Weight: 350.24 (anhydrous basis)
Linear Formula: KVO5C12H8N2 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0889-5MG 5 mg
 $85.20
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45-SML0889-25MG 25 mg
 $302.00
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assay ≥95% V basis
color faintly yellow to dark yellow
form powder
InChI 1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;
InChI key MQPXOTNOFVCXDA-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]
solubility H2O: 20 mg/mL, clear
storage condition protect from light
storage temp. −20°C
Biochem/physiol Actions: bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.
Biochem/physiol Actions: bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.
Biochem/physiol Actions: bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.
Other Notes: Light Sensitive
Packaging: 5, 25 mg in glass bottle
Purity ≥95% V basis
Storage Temp. −20°C
UNSPSC 12352200

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