SB 452533
SIGMA/SML0890 - ≥98% (HPLC)
Synonym: N-(2-Bromophenyl)-N′-[2-[ethyl(3-methylphenyl)amino]ethyl]urea; SB-452533
CAS Number: 459429-39-1
Empirical Formula (Hill Notation): C18H22BrN3O
Molecular Weight: 376.29
Linear Formula: C18H22BrN3O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | yellow to orange |
form | powder |
Quality Level | 100 |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | room temp |
Biochem/physiol Actions: | SB-452533 acts as a competitive inhibitor at the capsaicin binding site on the transient receptor potential channel TRPV1 receptor with a pKb of 7.7 versus capsaicin and pIC50 of 7.0 versus pH. At higher concentrations, SB-452533 is also active at TRPM8 with an IC50 of 571 nM. It has a high clearance rate, so is not suitable for in vivo use. |
Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07,GHS09 |
Signal word | Warning |
Hazard statements | H302 - H410 |
Precautionary statements | P273 - P501 |
Hazard Codes | N |
Risk Statements | 50/53 |
Safety Statements | 60-61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | room temp |
UNSPSC | 12352200 |